Association of class I histone deacetylases with transcriptional corepressor CtBP.

@article{Subramanian2003AssociationOC,
  title={Association of class I histone deacetylases with transcriptional corepressor CtBP.},
  author={Thirugnana Subramanian and G. Chinnadurai},
  journal={FEBS letters},
  year={2003},
  volume={540 1-3},
  pages={255-8}
}
The C-terminal binding protein (CtBP) family proteins are transcriptional regulators that are conserved from worm to human. They function as corepressors of a wide array of DNA-binding transcriptional repressors. The mammalian CtBPs appear to mediate transcriptional repression in a histone deacetylase (HDAC)-dependent or -independent manner, depending on the context of the promoter. To identify the components of the CtBP corepressor complex, we isolated CtBP-containing protein complexes from… CONTINUE READING