Association of circulating sclerostin with bone mineral mass, microstructure, and turnover biochemical markers in healthy elderly men and women.

@article{Durosier2013AssociationOC,
  title={Association of circulating sclerostin with bone mineral mass, microstructure, and turnover biochemical markers in healthy elderly men and women.},
  author={Claire Durosier and Antoon H J M van Lierop and Serge Ferrari and Thierry Chevalley and Socrates E Papapoulos and Ren{\'e} R Rizzoli},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2013},
  volume={98 9},
  pages={3873-83}
}
CONTEXT Sclerostin inhibits bone formation and is involved in the bone response to mechanical loading, but the role and significance of circulating sclerostin are poorly understood. OBJECTIVE We assessed the association between serum sclerostin and calcitropic hormones, bone turnover marker levels, bone mineral content/density, and microstructure using 3 different immunoassays. DESIGN, SETTING, AND PARTICIPANTS In a cross-sectional study, serum sclerostin was measured in a cohort of 187… CONTINUE READING