Association of childhood rhabdomyosarcoma with neurofibromatosis type I and birth defects.

@article{Yang1995AssociationOC,
  title={Association of childhood rhabdomyosarcoma with neurofibromatosis type I and birth defects.},
  author={Ping Yang and Seymour Grufferman and Muin J. Khoury and Ann Grossbart Schwartz and Jeanne Kowalski and Frederick B. Ruymann and Harold M. Maurer},
  journal={Genetic epidemiology},
  year={1995},
  volume={12 5},
  pages={467-74}
}
Rhabdomyosarcoma (RMS) is an uncommon malignant soft tissue sarcoma whose cause is largely unknown. Reported risk factors include genetic alterations (e.g., p53 mutations, a defective gene at 11p15.5, or specific chromosomal translocation of t(2:13)), and parents' use of drugs around the time of conception. We present results from a national, case-control study of 249 RMS cases (170 males and 79 females) and 302 controls (196 males and 106 females). The cases, aged 0-20 years at diagnosis, were… CONTINUE READING

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