Association of childhood rhabdomyosarcoma with neurofibromatosis type i and birth defects

@article{Yang1995AssociationOC,
  title={Association of childhood rhabdomyosarcoma with neurofibromatosis type i and birth defects},
  author={P. Y. Yang and Seymour Grufferman and M J Khoury and A Schwartz and J Kowalski and Frederick B. Ruymann and Harold M. Maurer},
  journal={Genetic Epidemiology},
  year={1995},
  volume={12}
}
Rhabdomyosarcoma (RMS) is an uncommon malignant soft tissue sarcoma whose cause is largely unknown. Reported risk factors include genetic alterations (e.g., p53 mutations, a defective gene at 11p15.5, or specific chromosomal translocation of t(2:13)), and parents' use of drugs around the time of conception. We present results from a national, case‐control study of 249 RMS cases (170 males and 79 females) and 302 controls (196 males and 106 females). The cases, aged 0–20 years at diagnosis, were… 
Family history of cancer and childhood rhabdomyosarcoma: a report from the Children's Oncology Group and the Utah Population Database
TLDR
In the largest analysis of its kind, the results indicate an increased risk of RMS in children who have a first‐degree relative with cancer, and among those whose relatives were diagnosed with cancer at <30 years of age.
Germline Cancer-Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report from the Children's Oncology Group.
TLDR
It is demonstrated that genetic risk of RMS results from germline predisposition variants associated with a wide spectrum of cancer-susceptibility syndromes, which is in contrast to current genetic testing recommendations based on early age at diagnosis.
Rhabdomyosarcoma in a patient with cardio-facio-cutaneous syndrome.
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There could be a higher risk of malignancy in patients with syndromes in the Noonan phenotype category, and other reports suggest there could be an increase in the number of patients diagnosed with CFC-s with rhabdomyosarcoma.
Maternal and birth characteristics and childhood rhabdomyosarcoma: a report from the Children’s Oncology Group
TLDR
Overall, it is found little evidence that these maternal and birth characteristics are strongly associated with childhood rhabdomyosarcoma, and statistically significant, was abnormal vaginal bleeding during pregnancy.
Second Malignant Neoplasms in Patients With Rhabdomyosarcoma
TLDR
The multivariate analysis indicated that RMS in the limbs and earlier diagnosis time were independent risk factors for the development of SMN, which is helpful for the personalized screening of high-risk patients with RMS.
Second Malignant Neoplasms in Patients with Rhabdomyosarcoma: A US Population-Based Analysis
TLDR
The multivariate analysis indicated that RMS in the limbs and earlier diagnosis time were independent risk factors for the development of SMN, which is helpful for the personalized screening of high-risk patients with RMS.
Allergies, atopy, immune‐related factors and childhood rhabdomyosarcoma: A report from the children's oncology group
TLDR
This is the first study indicating that atopic exposures may be protective against childhood RMS, suggesting additional studies are needed to evaluate the immune system's role in the development of this tumor.
Rhabdomyosarcoma
TLDR
This Primer describes the current understanding of RMS epidemiology, disease susceptibility factors, disease mechanisms and elements of clinical care, including diagnostics, risk-based care of newly diagnosed and relapsed disease and the prevention and management of late effects in survivors.
Prenatal X-ray Exposure and Rhabdomyosarcoma in Children: A Report from the Children's Oncology Group
TLDR
Findings in this study are compatible with findings from animal studies in which Ptc heterozygous knockout mice exhibited an increased risk of radiation-induced development defects and of spontaneously occurring embryonal rhabdomyosarcoma.
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