Association of childhood rhabdomyosarcoma with neurofibromatosis type i and birth defects

@article{Yang1995AssociationOC,
  title={Association of childhood rhabdomyosarcoma with neurofibromatosis type i and birth defects},
  author={P. Y. Yang and Seymour Grufferman and M J Khoury and A Schwartz and Joseph Kowalski and Frederick B. Ruymann and Harold M. Maurer},
  journal={Genetic Epidemiology},
  year={1995},
  volume={12}
}
Rhabdomyosarcoma (RMS) is an uncommon malignant soft tissue sarcoma whose cause is largely unknown. Reported risk factors include genetic alterations (e.g., p53 mutations, a defective gene at 11p15.5, or specific chromosomal translocation of t(2:13)), and parents' use of drugs around the time of conception. We present results from a national, case‐control study of 249 RMS cases (170 males and 79 females) and 302 controls (196 males and 106 females). The cases, aged 0–20 years at diagnosis, were… 

Family history of cancer and childhood rhabdomyosarcoma: a report from the Children's Oncology Group and the Utah Population Database

TLDR
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TLDR
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TLDR
Examination of epidemiological reports of RMS incidence in terms of several factors, including age at diagnosis, biological sex, and geographic location reveals the role of parental exposures, birth and perinatal characteristics, and childhood exposures in RMS.

Second Malignant Neoplasms in Patients With Rhabdomyosarcoma

TLDR
The multivariate analysis indicated that RMS in the limbs and earlier diagnosis time were independent risk factors for the development of SMN, which is helpful for the personalized screening of high-risk patients with RMS.

Second Malignant Neoplasms in Patients with Rhabdomyosarcoma: A US Population-Based Analysis

TLDR
The multivariate analysis indicated that RMS in the limbs and earlier diagnosis time were independent risk factors for the development of SMN, which is helpful for the personalized screening of high-risk patients with RMS.

Allergies, atopy, immune‐related factors and childhood rhabdomyosarcoma: A report from the children's oncology group

TLDR
This is the first study indicating that atopic exposures may be protective against childhood RMS, suggesting additional studies are needed to evaluate the immune system's role in the development of this tumor.

Rhabdomyosarcoma

TLDR
This Primer describes the current understanding of RMS epidemiology, disease susceptibility factors, disease mechanisms and elements of clinical care, including diagnostics, risk-based care of newly diagnosed and relapsed disease and the prevention and management of late effects in survivors.
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References

SHOWING 1-10 OF 27 REFERENCES

Neurofibromatosis and childhood tumors

TLDR
It is concluded that clinically significant tumors in children with NF, not all of which are histologically malignant, are not rare and there is no contraindication to aggressive therapy.

Neurofibromatosis type I and malignancy: review of 32 pediatric cases treated at a single institution.

TLDR
Thirty-two cases of neurofibromatosis Type I (NF1) were identified among 6,678 pediatric cancer patients treated at St. Jude Children's Research Hospital over a 29-year period, reflecting the molecular and cytogenetic abnormalities that can be present in NF1 and the variety of tumors that may result in these patients.

Second malignant neoplasms in children treated for rhabdomyosarcoma. Intergroup Rhabdomyosarcoma Study Committee.

  • R. HeynV. Haeberlen H. Maurer
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1993
TLDR
The results of this study suggest that genetic abnormalities play a prominent role in the development of an SMN after therapy for a primary RMS and Chemotherapy with an alkylating agent and radiotherapy play significant roles in theDevelopment of anSMN compared with patients who received only one of these therapeutic modalities.

Neurofibromatosis in children with soft tissue sarcoma.

TLDR
It is suggested that NF may be more common in children with soft tissue sarcoma than previously thought and that clinicians should be alert for signs and symptoms of NF in such children and their families.

Cancer in the families of children with soft tissue sarcoma

TLDR
It is concluded that a marked proportion of childhood soft tissue sarcoma has a genetic basis and a subgroup of children whose relatives are at high risk of early onset cancer is identified.

Congenital anomalies associated with rhabdomyosarcoma: an autopsy study of 115 cases. A report from the Intergroup Rhabdomyosarcoma Study Committee (representing the Children's Cancer Study Group, the Pediatric Oncology Group, the United Kingdom Children's Cancer Study Group, and the Pediatric Inter

TLDR
Extensive epidemiologic studies now in progress in patients with rhabdomyosarcoma should provide the incidence of congenital anomalies and potential linkage with prenatal events and support a different gene locus operative on chromosome 11 for individuals with r Habdomyosa compared to Wilms' tumor.

Molecular differential pathology of rhabdomyosarcoma

TLDR
The underlying simplicity of the strategy used to define rhabdomyosarcoma subtypes with molecular markers suggests a model by which tumors can be unequivocally identified, which may apply equally well to other human solid tumors.

Incidence, types, and management of cancer in patients with neurofibromatosis.

TLDR
The authors discuss the dysplastic and malignant features associated with NF and the concept of NF as a "neurocristopathy".