Association of cellular thiol redox status with mitogen-induced calcium mobilization and cell cycle progression in human fibroblasts.

@article{Mallery1991AssociationOC,
  title={Association of cellular thiol redox status with mitogen-induced calcium mobilization and cell cycle progression in human fibroblasts.},
  author={Susan R. Mallery and Harold Laufman and Chuck Solt and Ralph Eugene Stephens},
  journal={Journal of cellular biochemistry},
  year={1991},
  volume={45 1},
  pages={
          82-92
        }
}
  • Susan R. Mallery, Harold Laufman, +1 author Ralph Eugene Stephens
  • Published in
    Journal of cellular…
    1991
  • Medicine, Biology
  • Human gingival fibroblast cultures were used to investigate the role of cellular thiol redox status in the mitogenic response. Increases in intracellular Ca2+ and cell cycle progression beyond G1 were followed as parameters of cellular mitogen-induced responses. Ethionine provided a G1 stage synchronization and altered the cellular redox poise as measured by the ratio NAD(P)H/NAD(P)+. Cultures harvested immediately after the 6 day ethionine low-serum synchronization showed a significant… CONTINUE READING

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    The biology of cell reproduction

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