Association of cathepsin E deficiency with development of atopic dermatitis.

@article{Tsukuba2003AssociationOC,
  title={Association of cathepsin E deficiency with development of atopic dermatitis.},
  author={Takayuki Tsukuba and Kuniaki Okamoto and Yoshiko Okamoto and Michiyo Yanagawa and Keiko Kohmura and Yoshiyuki Yasuda and Hiroshi Uchi and Takeshi Nakahara and Masutaka Furue and Keiko Nakayama and Tomoko Kadowaki and Kenji Yamamoto and Keiichi I. Nakayama},
  journal={Journal of biochemistry},
  year={2003},
  volume={134 6},
  pages={
          893-902
        }
}
Atopic dermatitis (AD) is a pruritic inflammatory skin diseases associated with a family history of atropy. Here we show that mice lacking the endolysosomal aspartic proteinase cathepsin E spontaneously develop skin lesions similar to those of humans with AD when reared under conventional conditions but not under specific pathogen-free conditions. These mice showed the increase in the ratio of CD4+/CD8+ T cells, the strong polarization of naïve T cells to T helper 2 cells, and the systemic… Expand
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