Association of cathepsin E deficiency with development of atopic dermatitis.

  title={Association of cathepsin E deficiency with development of atopic dermatitis.},
  author={Takayuki Tsukuba and Kuniaki Okamoto and Yoshiko Okamoto and Michiyo Yanagawa and Keiko Kohmura and Yoshiyuki Yasuda and Hiroshi Uchi and Takeshi Nakahara and Masutaka Furue and Keiko Nakayama and Tomoko Kadowaki and Kenji Yamamoto and Keiichi I. Nakayama},
  journal={Journal of biochemistry},
  volume={134 6},
Atopic dermatitis (AD) is a pruritic inflammatory skin diseases associated with a family history of atropy. Here we show that mice lacking the endolysosomal aspartic proteinase cathepsin E spontaneously develop skin lesions similar to those of humans with AD when reared under conventional conditions but not under specific pathogen-free conditions. These mice showed the increase in the ratio of CD4+/CD8+ T cells, the strong polarization of naïve T cells to T helper 2 cells, and the systemic… Expand
Cellular and molecular mechanisms in atopic dermatitis.
This review discusses recent advances in the understanding of the abnormal skin barrier in AD, namely abnormalities in epidermal structural proteins, such as filaggrin, mutated in approximately 15% of patients with AD,Epidermal lipids, and epidersmal proteases and protease inhibitors, and the mechanisms of susceptibility of AD skin lesions to microbial infections and the role of microbial products in exacerbating skin inflammation. Expand
Skin inflammation in RelB(-/-) mice leads to defective immunity and impaired clearance of vaccinia virus.
Allergic inflammation in RelB(-/-) mice is associated with dysregulated immunity to VV encountered via the skin, and it is speculated that susceptibility of AD patients to overwhelming vaccinia virus infection is similarly related to ineffective T cell responses. Expand
Transgenic Atopic Dermatitis-like Rat Model
Atopic dermatitis (AD) is one of the most common and severe skin diseases, and is primarily a disease of infancy and childhood. Although a number of mouse models for human AD have been developed,Expand
Allergic Airway Inflammation in Mice Deficient for the Antigen-Processing Protease Cathepsin E
In vivo, Ctse deficiency led to reduced lymphocyte influx after allergen sensitization and challenge in both investigated airway inflammation models, compared to their control groups. Expand
Study of the role of the thymic stromal lymphopoietin (TSLP) in the atopic march
This work demonstrated that keratinocytic TSLP is essentially required not only for the development of allergic skin inflammation, but also for the generation of the allergen-specific immune response, and demonstrated that T SLP-induced Th2 response requires an orchestrated cooperation of dendritic cells, CD4+ T cells and basophils. Expand
Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors.
An essential role of cathepsin E in immune defense against invading microorganisms is indicated, most probably due to regulation of the cell surface expression of TLR family members required for innate immune responses. Expand
Animal models of atopic dermatitis.
Since the description of the Nc/Nga mouse as a spontaneously occurring model of AD, a number of other mouse models of AD have been developed, which resulted in a better understanding of the pathogenesis of AD. Expand
Mouse Models of Atopic Eczema Critically Evaluated
The currently available mouse models of AE are reviewed in light of the novel World Allergy Organization classification of eczematous skin diseases and evaluated according to their clinical, histopathological and immunological findings. Expand
The role of cathepsin E in terminal differentiation of keratinocytes
It is suggested that in keratinocytes CatE is functionally linked to the expression of terminal differentiation markers, thereby regulating epidermis formation and homeostasis, and enhancing the keratinocyte terminal differentiation process. Expand
Modeling the tertiary structure of human cathepsin-E.
  • K. Chou
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • 2005
The computed three-dimensional structure of cathepsin-E and the relevant findings might provide useful insights for designing inhibitors with the desired selectivity in the development of drugs for the therapy of Alzheimer's disease or breast cancer. Expand