Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis.

@article{Mahurkar2006AssociationOC,
  title={Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis.},
  author={Swapna Mahurkar and Mohammed M. Idris and Dr. K. Narotham Reddy and S. Venkata Udaya Bhaskar and Guduru Venkat Rao and Varghese Anthony Thomas and L. Brojendra Singh and Giriraj Ratan Chandak},
  journal={Gut},
  year={2006},
  volume={55 9},
  pages={
          1270-5
        }
}
BACKGROUND AND AIMS Tropical calcific pancreatitis (TCP) is a type of chronic pancreatitis unique to countries in the tropics. Mutations in pancreatic secretory trypsin inhibitor (SPINK1) rather than cationic trypsinogen (PRSS1) explain the disease in only 50% of TCP patients. As cathepsin B (CTSB) is known to activate cationic trypsinogen, we attempted to understand the role of CTSB mutations in TCP. Evidence of epistatic interaction was investigated with the previously associated N34S SPINK1… CONTINUE READING
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