Association of catechol-O-methyltransferase (COMT) polymorphism and academic achievement in a Chinese cohort

@article{Yeh2009AssociationOC,
  title={Association of catechol-O-methyltransferase (COMT) polymorphism and academic achievement in a Chinese cohort},
  author={Ting-Kuang Yeh and Chun-Yen Chang and Chung-Yi Hu and Ting-Chi Yeh and Ming-Yeh Lin},
  journal={Brain and Cognition},
  year={2009},
  volume={71},
  pages={300-305}
}
Catechol-O-methyltransferase (COMT) is a methylation enzyme that catalyzes the degradation pathway and inactivation of dopamine. It is accepted widely as being involved in the modulation of dopaminergic physiology and prefrontal cortex (PFC) function. The COMT Val158Met polymorphism is associated with variation in COMT activity. COMT 158Met allele may be advantageous for PFC-related cognitive abilities; however, it is also associated with increased anxiety, depression, and emotional… CONTINUE READING

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