Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele.

@article{Kennedy2006AssociationOC,
  title={Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele.},
  author={Lorna J. Kennedy and S Quarmby and George M. Happ and Annette Barnes and Ian K. Ramsey and R M Dixon and Brian Catchpole and Clare Rusbridge and Peter A Graham and Nicolette Salmon Hillbertz and C Roethel and W Jean Dodds and N Carmichael and William E.R. Ollier},
  journal={Tissue antigens},
  year={2006},
  volume={68 1},
  pages={
          82-6
        }
}
Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown. 
Increased genetic risk or protection for canine autoimmune lymphocytic thyroiditis in Giant Schnauzers depends on DLA class II genotype.
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TLDR
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TLDR
MHC involvement in canine MG disease manifestation overlaps with loci identified in human studies and highlights the value of dogs as a model for genetic studies of naturally occurring diseases.
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TLDR
The disease shows a complex pattern of inheritance, but the observed DLA class II association with DH suggests a role for the immune system in the development of the disease.
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TLDR
It was apparent that different breeds had different MHC associations with canine IMHA, which is similar to the observation that different human ethnic groups can have different HLA associations with the same immune-mediated disease.
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TLDR
Given the reported role of NF-κB in many human autoimmune diseases, the results suggest CLT as an excellent genetic model for human thyroiditis.
Necrotizing meningoencephalitis of Pug dogs associates with dog leukocyte antigen class II and resembles acute variant forms of multiple sclerosis.
TLDR
P Pug Dog encephalitis (PDE) shares clinical features with the less common acute variant forms of MS, and NME of Pug Dogs may represent a naturally occurring canine model of certain idiopathic inflammatory disorders of the human central nervous system.
Association of canine juvenile generalized demodicosis with the dog leukocyte antigen system.
TLDR
It is suggested that an underlying DLA association exists with demodicosis in dogs and that this may represent an important immunological risk factor in the aetiology of this condition.
Identification of susceptibility and protective major histocompatibility complex haplotypes in canine diabetes mellitus.
TLDR
This is the first report of a comparative study of MHC and diabetes in a non-rodent species and showed that DQA1 alleles carrying arginine at codon 55 of D QA1 were increased in dogs with diabetes.
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TLDR
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