Association of cancer with AIDS-related immunosuppression in adults.

@article{Frisch2001AssociationOC,
  title={Association of cancer with AIDS-related immunosuppression in adults.},
  author={Morten Frisch and Robert J. Biggar and Eric A. Engels and James J. Goedert},
  journal={JAMA},
  year={2001},
  volume={285 13},
  pages={
          1736-45
        }
}
CONTEXT Large-scale studies are needed to determine if cancers other than Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer occur in excess in persons with human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS). OBJECTIVES To examine the general cancer pattern among adults with HIV/AIDS and to distinguish immunosuppression-associated cancers from other cancers that may occur in excess among persons with HIV/AIDS. DESIGN, SETTING, AND SUBJECTS… 

Tables from this paper

AIDS-related cancer and severity of immunosuppression in persons with AIDS.
TLDR
CD4 count was strongly associated with risks for Kaposi sarcoma and non-Hodgkin lymphoma but not for cervical cancer and Burkitt lymphoma, consistent with improving CD4 counts after HAART introduction in 1996.
Non-AIDS-defining cancers and HIV infection
TLDR
Although data regarding the optimal management of these cancers are lacking, current studies suggest that patients with HIV-associated malignancies should be treated with similar approaches to those of their counterparts in the general population.
Non—AIDS–Defining cancers and HIV infection
TLDR
Although data regarding the optimal management of these cancers are lacking, current studies suggest that patients with HIV-associated malignancies should be treated with similar approaches to those of their counterparts in the general population.
Epidemiology of AIDS-related malignancies an international perspective.
The growing problem of non-AIDS-defining malignancies in HIV
TLDR
It is unclear whether the growing number of reports on non-AIDS-defining cancers reflects a true increased incidence or merely the product of increased surveillance, detection and reporting.
Non-AIDS-defining cancers
TLDR
NADCs are contributing significantly to the morbidity and mortality of HIV infection in the era of highly active antiretroviral therapy and the risk of NADCs does not correlate with the degree of immunodeficiency in general.
Malignancies in HIV/AIDS: from epidemiology to therapeutic challenges
TLDR
Although the survival of newly infected people living with HIV/AIDS now rivals that of the general population, morbidity and mortality associated with non-AIDS-defining cancers such as lung, liver, anal, and melanoma are significant and also continue to rise.
...
...

References

SHOWING 1-10 OF 51 REFERENCES
Risk of Cancer in Children With AIDS
TLDR
The spectrum of AIDS-associated pediatric cancers resembled that seen in adults, with the addition of leiomyosarcoma, and RR estimates are imprecise and caution is warranted in their interpretation.
Spectrum of AIDS-associated malignant disorders
HIV-Related Malignancies: Community-Based Study using Linkage of Cancer Registry and HIV Registry Data
For people immunosuppressed by human immunodeficiency virus (HIV), we expect an increase in cancer incidence similar to that documented in transplant patients. We examined the cancer spectrum in an
The spectrum of Aids-associated cancers in Africa.
TLDR
The underestimation on increased ICC risk among HIV-infected women in Western countries based on the data from the African study is noted to be misleading and careful consideration should be made for the resulting public health implications.
The spectrum of acquired immunodeficiency syndrome (AIDS)-associated malignancies in San Francisco, 1980-1987.
TLDR
Compared with the concurrent reference population of the San Francisco Bay Area, there was little or no increase in Kaposi's sarcoma over the time interval of this study, but suggestively for non-Hodgkin's lymphoma, the temporal increase has been quite dramatic.
Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome.
TLDR
HPV-associated malignancies occur at increased rates in persons with HIV/AIDS, and increasing RRs for in situ cancers to and beyond the time of AIDS onset may reflect the gradual loss of control over HPV-infected keratinocytes with advancing immunosuppression.
Overview of the epidemiology of malignancy in immune deficiency.
  • N. Mueller
  • Medicine, Biology
    Journal of acquired immune deficiency syndromes
  • 1999
TLDR
Comparing the patterns of malignancy and immune parameters among these immune-incompetent populations and the general population may elucidate the role of host response in controlling latent oncogenic infections.
Increased incidence of Hodgkin disease in homosexual men with HIV infection.
TLDR
An excess incidence of Hodgkin disease was found in HIV-infected homosexual men and additional well-designed epidemiologic studies are needed to determine whether Hodgkins disease should be considered an HIV-related malignancy.
Cancer in human immunodeficiency virus-infected children: a case series from the Children's Cancer Group and the National Cancer Institute.
TLDR
After NHL, leiomyosarcoma is the second leading cancer in children with HIV infection and improved outcome for NHL, in particular, may depend on earlier diagnosis and therapy.
...
...