Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen.

@article{Widschwendter2004AssociationOB,
  title={Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen.},
  author={Martin Widschwendter and Kimberly D. Siegmund and Hannes M. M{\"u}ller and Heidi Fiegl and Christian Marth and Elisabeth Mueller-Holzner and Peter A. Jones and Peter W. Laird},
  journal={Cancer research},
  year={2004},
  volume={64 11},
  pages={
          3807-13
        }
}
We have generated DNA methylation profiles of 148 human breast tumors and found significant differences in hormone receptor (HR) status between clusters of DNA methylation profiles. Of 35 DNA methylation markers analyzed, the ESR1 gene, encoding estrogen receptor alpha, proved to be the best predictor of progesterone receptor status, whereas methylation of the PGR gene, encoding progesterone receptor, was the best predictor of estrogen receptor status. ESR1 methylation outperformed HR status as… CONTINUE READING

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