Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes.

@article{Baldwin2007AssociationOB,
  title={Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes.},
  author={Michael R Baldwin and Joseph T. Barbieri},
  journal={Biochemistry},
  year={2007},
  volume={46 11},
  pages={3200-10}
}
Botulinum neurotoxins (BoNTs) elicit flaccid paralysis through cleavage of SNARE proteins within peripheral neurons. There are seven serotypes of the BoNTs, termed A-G, which differ in the SNARE protein and/or site that is cleaved. BoNTs are single-chain toxins that comprise an N-terminal zinc metalloprotease domain that is disulfide linked to the C-terminal translocation/receptor binding domain. SV2 and synaptotagmin have been identified as receptors for BoNT serotypes A and B, respectively… CONTINUE READING

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