Association of biomarkers of inflammation and HLA-DRB1 gene locus with risk of developing rheumatoid arthritis in females

@article{Klimenta2019AssociationOB,
  title={Association of biomarkers of inflammation and HLA-DRB1 gene locus with risk of developing rheumatoid arthritis in females},
  author={Biljana Klimenta and Hilada Nefic and Nenad Prodanovic and Radivoj Jadric and Fatima Hukic},
  journal={Rheumatology International},
  year={2019},
  volume={39},
  pages={2147 - 2157}
}
Rheumatoid arthritis (RA) is an autoimmune disease causing chronic inflammation of the joints. Multiple factors, including HLA-DRB1 gene variants, influence the susceptibility to RA. The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. In this study, we compared the inflammatory biomarkers values, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), between patients with RA and healthy control group of females of the Public… Expand
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References

SHOWING 1-10 OF 26 REFERENCES
Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls
TLDR
In the Slovak population, HLA-DRB1 alleles as well as SNPs in STAT4 and PTPN22 genes showed a strong association with RA. Expand
Association of HLA-DR with susceptibility to and clinical expression of rheumatoid arthritis: re-evaluation by means of genomic tissue typing.
TLDR
DR4 was associated with susceptibility to RA in patients; HLA-DR low-resolution genomic tissue typing did not yield additional information to RF status for the clinical identification of individual patients with a poor prognosis. Expand
HLA‐DRB1 genes and disease severity in rheumatoid arthritis in Turkey
TLDR
The results suggest that the HLA‐DRB1 alleles, particularly HLA•DRB 1*04 and subtypes, were associated with RA. Expand
Diagnostic performance and predictive value of rheumatoid factor, anti-cyclic-citrullinated peptide antibodies and HLA-DRB1 locus genes in rheumatoid arthritis
TLDR
It is suggested that anti-CCP2 is superior to RF for the detection of RA and provided predictive information on joint destruction and disease activity. Expand
An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes.
TLDR
This work identified HLA-DRB1 alleles associated with SLE and RA in a Japanese population and demonstrated a shared susceptibility of DRB1*09:01 between the diseases as well as its effect on autoantibody production. Expand
HLA haplotype analysis in Finnish patients with rheumatoid arthritis.
TLDR
Both protection-associated and susceptibility-associated alleles can be found among HLA class II genes, and the results suggest that loci outside DR/DQ may contribute to the pathogenesis of RA. Expand
HLA-DRB1 alleles associated with susceptibility or resistance to rheumatoid arthritis, articular deformities, and disability in Mexican Americans.
TLDR
HLA-DRB1*08 appears to have a protective influence on RA susceptibility and disease severity in Mexican Americans, and may also be associated with a more rapid development of articular deformities and disability. Expand
Crosslinks Between Human Leukocyte Antigen DRB1*01 and Human Leukocyte Antigen DRB1*13 Allelic Variants and Occurrence of Rheumatoid Arthritis in Patients From Federation of Bosnia and Herzegovina.
TLDR
The most common genotype in RA patients was DRB1-01/DRB1*13, which showed increased frequency and a high relative risk, and may be considered a predisposing factor for the development of RA. Expand
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
TLDR
Seven new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 × 10−8) in an analysis of all 41,282 samples, and an additional 11 SNPs replicated at P < 0.05, suggesting that most represent genuine rhearatoid arthritisrisk alleles. Expand
HLA-DR1 and rheumatoid arthritis in Israeli Jews: sequencing reveals that DRB1*0102 is the predominant HLA-DR1 subtype.
TLDR
sequencing the first domain of the DRB1 gene in 12 DR1-positive Israeli RA patients, 5 healthy controls and a homozygous typing cell (HTC), defining the major Jewish cellular HLA-DR1 subtype found no basis for the reported extensive cellular heterogeneity of DR1 in the Israeli population. Expand
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