Association of apolipoprotein E polymorphism to clinical heterogeneity of multiple sclerosis.

@article{Ballerini2000AssociationOA,
  title={Association of apolipoprotein E polymorphism to clinical heterogeneity of multiple sclerosis.},
  author={Clara Ballerini and Daniela Campani and Giovanni Rombol{\'a} and Bruno Gran and Benedetta Nacmias and Maria Pia Amato and Gianfranco Siracusa and Luca Bartolozzi and Sandro Sorbi and Luca Massacesi},
  journal={Neuroscience letters},
  year={2000},
  volume={296 2-3},
  pages={174-6}
}
In this study we investigated the distribution of apolipoprotein E (APO E) genotypes in sporadic multiple sclerosis (MS) cases and in normal controls. Later onset of chronic progressive MS was observed in patients carrying the epsilon2 allele, whereas APO E alleles were found at similar frequency in MS and in the control population. These findings indicate that clinical heterogeneity, but probably not susceptibility to the disease, is associated to APO E genotypes. 

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