Association of antiphosphatidylserine/prothrombin antibodies with neuropsychiatric systemic lupus erythematosus

@article{Syuto2009AssociationOA,
  title={Association of antiphosphatidylserine/prothrombin antibodies with neuropsychiatric systemic lupus erythematosus},
  author={Tomoko Syuto and Akira Shimizu and Yuko Takeuchi and Setsuko Tanaka and Michiko Hasegawa and Yayoi Nagai and Atsushi Tamura and Osamu Ishikawa},
  journal={Clinical Rheumatology},
  year={2009},
  volume={28},
  pages={841-845}
}
Neuropsychiatric manifestations in patients with systemic lupus erythematosus (SLE) are well-recognized symptoms although the pathophysiology of neuropsychiatric SLE (NPSLE) is unclear. Since an association with antiphospholipid antibodies has been reported, we examined the prevalence of antiphosphatidylserine–prothrombin antibodies (anti-PS/PT Abs), lupus anticoagulant (LA), anticardiolipin/β2-glycoprotein I antibodies (anti-β2-GPI Abs), and antiribosomal P protein antibodies (antiribosomal P… 

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References

SHOWING 1-10 OF 18 REFERENCES

A followup study of antiphospholipid antibodies and associated neuropsychiatric manifestations in 137 children with systemic lupus erythematosus.

TLDR
The data suggest an association between LAC and cerebrovascular disease at the time of SLE diagnosis and chorea over the disease course, but not between aPL and other neuropsychiatric manifestations.

Autoantibodies against phosphatidylserine-prothrombin complex in patients with systemic sclerosis

TLDR
Examining the frequency and clinical association of antiphosphatidylserine-prothrombin complex (PS/PT) antibody (Ab) in systemic sclerosis (SSc) found it to be associated with thromboembolism, peripheral ischaemia, and lung involvement in some patients with SSc.

The presence of anti-phosphatidylserine/prothrombin antibodies as risk factor for both arterial and venous thrombosis in patients with systemic lupus erythematosus.

TLDR
It was showed that positive results of anti-beta2-GPI-ELISA and anti-PS/PT- ELISA could serve as markers of thrombotic complications in patients with SLE, whereas aCL andAnti-PT are less reliable as marker of these complications.

Neuropsychiatric manifestations in systemic lupus erythematosus: prevalence and association with antiphospholipid antibodies.

TLDR
The new ACR criteria for NPSLE are useful to define NP manifestations in SLE with accuracy and are significantly associated with antiphospholipid antibodies, which are independently associated with CVD, headache, and seizures.

Arteriosclerosis obliterans associated with anti-cardiolipin antibody/beta2-glycoprotein I antibodies as a strong risk factor for ischaemic heart disease in patients with systemic lupus erythematosus.

TLDR
The presence of aCL/beta2-GPI contributes to the risk of development of ASO, which may represent an important mechanism for the pathogenesis of IHD in patients with SLE.

Hemichorea with antiphospholipid antibodies in a patient with lupus nephritis

TLDR
A 7-year-old boy suffered from lupus nephritis and a left middle cerebral artery infarction and subsequently experienced two episodes of right hemichorea associated with increased aPLs levels without any evidence of further neurological lesions by brain computed tomography or magnetic resonance imaging.

Accuracy of anti-ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus: an international meta-analysis.

TLDR
Anti-P antibody testing has limited diagnostic value for NPSLE, and it is not helpful in differentiating among various disease phenotypes.

Strong correlation between the prevalence of cerebral infarction and the presence of anti-cardiolipin/beta2-glycoprotein I and anti-phosphatidylserine/prothrombin antibodies--Co-existence of these antibodies enhances ADP-induced platelet activation in vitro.

TLDR
Results indicate that anti-CL/beta2-GPI and anti-PS/PT may cooperate to promote platelet activation, which may contribute to the risk of cerebral infarction in patients with SLE.

Neuropsychiatric events in systemic lupus erythematosus: attribution and clinical significance.

TLDR
In patients with SLE, NP disease has diverse manifestations and can be attributed to lupus in roughly half of the cases, and the occurrence of NP disease is associated with a significant reduction in quality of life.