Association of antiphosphatidylserine/prothrombin autoantibodies with HLA class II genes.

@article{Bertolaccini2000AssociationOA,
  title={Association of antiphosphatidylserine/prothrombin autoantibodies with HLA class II genes.},
  author={Maria Laura Bertolaccini and Tatsuya Atsumi and Araceli C{\'a}liz and Olga Amengual and Munther A. Khamashta and Graham R. V. Hughes and T. Koike},
  journal={Arthritis and rheumatism},
  year={2000},
  volume={43 3},
  pages={683-8}
}
OBJECTIVE To investigate the associations between HLA class II genes and antiphosphatidylserine/prothrombin antibodies (aPS/PT) in a group of British caucasoid patients with antiphospholipid antibodies (aPL). METHODS This study included 82 patients with aPL. IgG aPS/PT were detected in sera using enzyme-linked immunosorbent assays. HLA-DQB1, DQA1, and DRB1 genotypes were determined by polymerase chain reaction using sequence-specific primers. All results were compared with 177 matched healthy… CONTINUE READING