Association of antigen-stimulated release of tumor necrosis factor-alpha in whole blood with response to chemotherapy in patients with pulmonary multidrug-resistant tuberculosis.

@article{Eum2010AssociationOA,
  title={Association of antigen-stimulated release of tumor necrosis factor-alpha in whole blood with response to chemotherapy in patients with pulmonary multidrug-resistant tuberculosis.},
  author={S S Eum and Ye-Jin Lee and Jin-Hong Min and Hyun-Kyung Kwak and M Hong and Ji-Hye Kong and Soo-Hee Hwang and Seung-Kyu Park and Jason J Leblanc and Laura E Via and Clifton E Barry and S. -T. Cho},
  journal={Respiration; international review of thoracic diseases},
  year={2010},
  volume={80 4},
  pages={275-84}
}
BACKGROUND We have previously reported that TNF-α levels correlate to total mycobacterial burden in tuberculosis (TB) patients. OBJECTIVE To characterize the dynamics of cytokine responses in TB patients during chemotherapy to identify potential surrogate markers for effective treatment. METHODS Following induction by culture filtrate proteins in whole blood, production patterns of TNF-α, IL-10, IFN-γ and IL-12 were measured in 23 non-multidrug-resistant (MDR)-TB and 16 MDR-TB patients and… CONTINUE READING
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