Association of angiotensin-converting enzyme insertion/deletion polymorphism with susceptibility to systemic lupus erythematosus: a meta-analysis.

@article{Huang2018AssociationOA,
  title={Association of angiotensin-converting enzyme insertion/deletion polymorphism with susceptibility to systemic lupus erythematosus: a meta-analysis.},
  author={An-Fang Huang and Hui Li and Lei Ke and Chao Yang and Xiaoyan Liu and Zu-Cheng Yang and Fen Xu and Hong Yan Jia and Wang-Dong Xu},
  journal={International journal of rheumatic diseases},
  year={2018},
  volume={21 2},
  pages={
          447-457
        }
}
BACKGROUND The aim of this study was to determine whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism confers susceptibility to systemic lupus erythematosus (SLE)/lupus nephritis (LN). METHODS A meta-analysis was conducted on the association between the ACE I/D polymorphism and SLE/LN (when available) using: (i) the allelic contrast; (ii) the recessive; (iii) the dominant; and (iv) the additive models. RESULTS A total of 27 relevant comparisons meeting… CONTINUE READING

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