Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock.

@article{Nakada2011AssociationOA,
  title={Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock.},
  author={Taka-aki Nakada and James A Russell and John H. Boyd and Luke McLaughlin and Emiri Nakada and Simone A. Thair and Hiroyuki Hirasawa and Shigeto Oda and Keith R. Walley},
  journal={Critical care medicine},
  year={2011},
  volume={39 7},
  pages={
          1641-8
        }
}
OBJECTIVE Angiotensin II and its postreceptor signaling are crucial in regulating vasomotor tone. The objective of this study was to test the hypothesis that single nucleotide polymorphisms in angiotensin II pathway genes alter outcome of septic shock. DESIGN Genetic association study and in vitro experiment. SETTING Intensive care units at academic teaching centers. PATIENTS Derivation and validation septic shock cohorts (n = 589 and n = 616, respectively) and a coronary artery bypass… CONTINUE READING

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