Association of an interleukin 1 alpha polymorphism with Alzheimer's disease.

  title={Association of an interleukin 1 alpha polymorphism with Alzheimer's disease.},
  author={Yansheng Du and Richard C. Dodel and Brian J. Eastwood and Kelly R. Bales and Fuqiang Gao and Frank Lohm{\"u}ller and Ulrich Mueller and Alexander Kurz and Reinhilde Zimmer and Rebecca M Evans and Ann Marie Hake and Thomas Gasser and Wolfgang Hermann Oertel and W. Sue T. Griffin and Steven M Paul and Martin R. Farlow},
  volume={55 4},
BACKGROUND Retrospective epidemiologic studies suggest that individuals exposed to anti-inflammatory agents such as nonsteroidal anti-inflammatory drugs have a lower probability of developing AD as well as an older age at onset for the illness. Neuroinflammation may play an important role in the pathogenesis of AD. Interleukin 1 (IL-1), a potent proinflammatory cytokine, is colocalized immunohistochemically to neuritic plaques, a requisite neuropathologic feature for AD. A polymorphism in the 5… CONTINUE READING
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