Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.

@article{Tsui2010AssociationOA,
  title={Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.},
  author={Florence W L Tsui and Nigil Haroon and John D Reveille and Proton Rahman and Basil Chiu and Hing Wo Tsui and Robert D. Inman},
  journal={Annals of the rheumatic diseases},
  year={2010},
  volume={69 4},
  pages={733-6}
}
OBJECTIVES To assess whether there is excess transmission of alleles from the ERAP1 ERAP2 locus in families with ankylosing spondylitis (AS). METHODS 199 multiplex families with AS with four non-synonymous single nucleotide polymorphisms (SNPs), three in the endoplasmic reticulum aminopeptidase 1 (ERAP1) gene (rs27044, rs10050860 and rs30187) and one in the endoplasmic reticulum aminopeptidase 2 (ERAP2) gene (rs2549782), were genotyped and family-based association analyses were performed… CONTINUE READING