Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset.

Abstract

The alpha-synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80-5.87). Survival analyses (Cox proportional hazards models) were employed to explore the influence of genotypes on age at onset of PD. Age at onset of carriers of at least one Rep1 allele 2 was earlier (3.6 years) compared to noncarriers (adjusted hazard ratio = 2.21; 95% CI = 1.58-3.10). Kaplan-Meier analysis also supported a dosage effect of Rep1 allele 2 on age at onset. For Rep1 allele 1, there was neither association with risk of PD nor influence on age at onset. This is the first study showing an influence of Rep1 polymorphism on age at onset of PD.

0100200300'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

751 Citations

Semantic Scholar estimates that this publication has 751 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Hadjigeorgiou2006AssociationOA, title={Association of alpha-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset.}, author={Georgios Hadjigeorgiou and Georgia Xiromerisiou and Vanessa Gourbali and Kostantinos Aggelakis and Nikolaos Scarmeas and Alexandros Papadimitriou and Andrew Singleton}, journal={Movement disorders : official journal of the Movement Disorder Society}, year={2006}, volume={21 4}, pages={534-9} }