Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease.

  title={Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease.},
  author={Kenya Nishioka and Christian Wider and Carles Vilari{\~n}o-G{\"u}ell and Alexandra I. Soto-Ortolaza and Sarah J. Lincoln and Jennifer M. Kachergus and Barbara Jasińska-Myga and Owen A. Ross and Alex Rajput and Christopher Adam Robinson and Tanis J. Ferman and Zbigniew K Wszolek and Dennis W. Dickson and Matthew John Farrer},
  journal={Archives of neurology},
  volume={67 8},
OBJECTIVE To determine the association of the genes that encode alpha-, beta-, and gamma-synuclein (SNCA, SNCB, and SNCG, respectively) with diffuse Lewy body disease (DLBD). DESIGN Case-control study. Subjects A total of 172 patients with DLBD consistent with a clinical diagnosis of Parkinson disease dementia/dementia with Lewy bodies and 350 clinically and 97 pathologically normal controls. INTERVENTIONS Sequencing of SNCA, SNCB, and SNCG and genotyping of single-nucleotide polymorphisms… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 26 extracted citations

The Function of α-Synuclein

View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…