Association of age with the level of response in the QuantiFERON-TB Gold In-Tube assay for children with active tuberculosis.

@article{Markova2011AssociationOA,
  title={Association of age with the level of response in the QuantiFERON-TB Gold In-Tube assay for children with active tuberculosis.},
  author={Roumiana Markova and Rumiana Drenska and Petko Minchev and Yana Todorova and Massimo Ciccozzi and M Amicosante},
  journal={The new microbiologica},
  year={2011},
  volume={34 1},
  pages={81-5}
}
QuantiFERON-TB data from 50 children with tuberculosis were analysed to evaluate age related effects. Significantly higher IFN-? responses to TB-specific antigens were associated with younger age, but no difference was found with Mitogen responses. Extrapolating IGRA responses to a Mitogen does not reflect those induced by an antigen-specific stimulus. QFT-IT responses to TB-specific antigens are not compromised with young age. 

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