Association of aflatoxin exposure and height-for-age among young children in Guatemala

@article{VothGaeddert2018AssociationOA,
  title={Association of aflatoxin exposure and height-for-age among young children in Guatemala},
  author={Lee E. Voth-Gaeddert and Matthew Stoker and Olga Torres and Daniel B. Oerther},
  journal={International Journal of Environmental Health Research},
  year={2018},
  volume={28},
  pages={280 - 292}
}
Abstract Aflatoxin exposure has been proposed to affect child height-for-age. The following hypothesized associations were tested in Guatemala: (1) aflatoxin (B1, B2, G1, G2) exposure and environmental enteric dysfunction (EED) and child height-for-age z-score; and (2) aflatoxin exposures and subsequent symptoms of aflatoxins. Maize consumption data, health data, and samples of maize from households were collected from mothers and their children – under five – in October 2016 (n = 320) and… 

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References

SHOWING 1-10 OF 39 REFERENCES

Determinants of aflatoxin exposure in young children from Benin and Togo, West Africa: the critical role of weaning.

TLDR
Exposure to this common toxic contaminant of West African food increases markedly following weaning and exposure early in life is associated with reduced growth, reinforcing the need for aflatoxin exposure intervention strategies within high-risk countries.

Association between aflatoxin exposure and health characteristics, liver function, hepatitis and malaria infections in Ghanaians

TLDR
The relationship between various health parameters and aflatoxin B1 (AFB1) albumin adduct levels in plasma was examined and significantly higher levels of AFB1 were obtained for participants who reported symptoms of acute aflatoxicosis.

Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions.

TLDR
The strategy of using food additives to protect farm animals from the toxin may also provide effective and economical new approaches to protecting human populations.

Food chain mycotoxin exposure, gut health, and impaired growth: a conceptual framework.

TLDR
Evidence from human and animal studies that exposure to mycotoxins, particularly aflatoxin (AF), fumonisin (FUM), and deoxynivaenol (DON), may impair child growth is reviewed and the role of mycotoxin in the pathogenesis of EE is proposed.

Mycotoxin Control in Low- and Middle-income Countries

TLDR
It is concluded that surveillance data on exposure to aflatoxins are generally lacking outside the developed countries, however, available data from measurements of contaminated crops and through the use of exposure biomarkers in exposed populations demonstrate that mycotoxin exposures can be high throughout Africa, as well as in Latin America and parts of Asia.

What causes childhood stunting among children of San Vicente, Guatemala: Employing complimentary, system-analysis approaches.

Aflatoxin and viral hepatitis exposures in Guatemala: Molecular biomarkers reveal a unique profile of risk factors in a region of high liver cancer incidence

TLDR
Substantial AFB1 exposure exists in Guatemalan adults, concurrent with low prevalence of hepatitis virus seropositivity, and exposures are similar to those previously found to increase risk for liver cancer in Asia and Africa.

Gross intestinal adaptations in relation to broiler performance during chronic aflatoxin exposure.

TLDR
Interestingly, a compensatory linear increase in the length of the duodenum and jejunum under high AFB(1) diets was noted to occur during wk 4 of exposure, which indicates that the intestine in broilers may adapt to an ongoing dietary challenge to AFB( 1).

Earlier introduction of aguitas is associated with higher risk of stunting in infants and toddlers in the Western Highlands of Guatemala.

TLDR
The prevalence and timing of the introduction of agüitas during early life in a low-income population of metropolitan Quetzaltenango in relation to stunting in children is examined to clarify the causal relations.

Environmental health and household demographics impacting biosand filter maintenance and diarrhea in Guatemala: an application of structural equation modeling.

TLDR
Estimating the effect of various environmental health factors and household demographics on the operation and maintenance of the Biosand filter and diarrhea health burden in rural Guatemala indicated the filter, though protective of health, is not the only factor influencing diarrhea.