Association of adverse childhood environment and 5-HTTLPR Genotype with late-life depression.

@article{Ritchie2009AssociationOA,
  title={Association of adverse childhood environment and 5-HTTLPR Genotype with late-life depression.},
  author={Karen Ritchie and Isabelle Jaussent and Robert Stewart and A E Dupuy and Philippe Courtet and M-L. Ancelin and Alain Malafosse},
  journal={The Journal of clinical psychiatry},
  year={2009},
  volume={70 9},
  pages={1281-8}
}
OBJECTIVE Neurobiological and clinical studies suggest that childhood maltreatment may result in functional and structural nervous system changes that predispose the individual to depression. This vulnerability appears to be modulated by a polymorphism in the serotonin gene-linked promoter region (5-HTTLPR). Little is known, however, about the persistence of this vulnerability across the life span, although clinical studies of adult populations suggest that gene-environment interaction may… CONTINUE READING
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