Association of advanced glycation end products with A549 cells, a human pulmonary epithelial cell line, is mediated by a receptor distinct from the scavenger receptor family and RAGE.

@article{Nakano2006AssociationOA,
  title={Association of advanced glycation end products with A549 cells, a human pulmonary epithelial cell line, is mediated by a receptor distinct from the scavenger receptor family and RAGE.},
  author={Nahoko Nakano and Kaori Fukuhara-Takaki and Tadashi Jono and Keisuke Nakajou and Nobuaki Eto and Seikoh Horiuchi and Motohiro Takeya and Ryoji Nagai},
  journal={Journal of biochemistry},
  year={2006},
  volume={139 5},
  pages={821-9}
}
Cellular interactions with advanced glycation end products (AGE)-modified proteins are known to induce several biological responses, not only endocytic uptake and degradation, but also the induction of cytokines and growth factors, combined responses that may be linked to the development of diabetic vascular complications. In this study we demonstrate that A549 cells, a human pulmonary epithelial cell line, possess a specific binding site for AGE-modified bovine serum albumin (AGE-BSA) (K(d… CONTINUE READING