Association of achieved dialysis dose with mortality in the hemodialysis study: an example of "dose-targeting bias".

@article{Greene2005AssociationOA,
  title={Association of achieved dialysis dose with mortality in the hemodialysis study: an example of "dose-targeting bias".},
  author={Tom Greene and John T. Daugirdas and Thomas A. Depner and Michael A Allon and Gerald Beck and Cameron Chumlea and James A. Delmez and Frank A. Gotch and John Walter Kusek and Nathan Levin and William Owen and Gerald I Schulman and Robert A Star and Robert M Toto and G. Garabed Eknoyan},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2005},
  volume={16 11},
  pages={3371-80}
}
In the intention-to-treat analysis of the Hemodialysis Study, all-cause mortality did not differ significantly between the high versus standard hemodialysis dose groups. The association of mortality with delivered dose within each of the two randomized treatment groups was examined, and implications for observational studies were considered. Time-dependent Cox regression was used to relate the relative risk (RR) for mortality to the running mean of the achieved equilibrated Kt/V (eKt/V) over… CONTINUE READING
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