Association of acetylcholine receptors with peripheral membrane proteins: evidence from antibody-induced coaggregation

@article{Bloch1994AssociationOA,
  title={Association of acetylcholine receptors with peripheral membrane proteins: evidence from antibody-induced coaggregation},
  author={Robert J. Bloch and Robert A. Sealock and David W. Pumplin and Paul W. Luther and Stanley C. Froehner},
  journal={The Journal of Membrane Biology},
  year={1994},
  volume={138},
  pages={13-28}
}
Acetylcholine receptors (AChR) are associated with several peripheral membrane proteins that are concentrated on the cytoplasmic face of the plasma membrane at the neuromuscular junction, and at aggregates of AChR that form in vitro. We tested the linkage among these proteins by inducing microaggregation of AChR, then determining if a given peripheral membrane protein accumulated with the receptors in microaggregates. In most experiments, we used isolated membrane fragments that are rich in… CONTINUE READING

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