Association of a single-nucleotide substitution in TYRP1 with roux in Japanese quail (Coturnix japonica).

@article{Nadeau2007AssociationOA,
  title={Association of a single-nucleotide substitution in TYRP1 with roux in Japanese quail (Coturnix japonica).},
  author={Nicola J Nadeau and Nicholas I. Mundy and David Gourichon and Francis Minvielle},
  journal={Animal genetics},
  year={2007},
  volume={38 6},
  pages={609-13}
}
We investigated TYRP1 as a candidate locus for the recessive, sex-linked roux (br(r)) phenotype in Japanese quail. A screen of the entire coding sequence of TYRP1 in roux and wild-type quail revealed a non-synonymous T-to-C substitution in exon 3, leading to a Phe282Ser mutation. This was perfectly associated with plumage phenotype: all roux birds were homozygous for Ser282. Co-segregation of the Phe282Ser mutation with the roux phenotype was confirmed in three br(r)/BR+ x br(r)/- backcrosses… CONTINUE READING