Association of a potential functional pre-miR-218 polymorphism and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk.

@article{Han2014AssociationOA,
  title={Association of a potential functional pre-miR-218 polymorphism and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk.},
  author={Yifang Han and Rui Pu and Xue Han and Jian Zhao and Weiping Li and Jianhua Yin and Yuwei Zhang and Qiuxia Shen and Jiaxin Xie and Qi Zhang and Shuang Shuang Jiang and Juhong Li and Hongwei Zhang and Hongyang Wang and Guangwen Cao},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2014},
  volume={34 5},
  pages={728-36}
}
BACKGROUND & AIMS MicroRNA-218 (miR-218) can function as a tumour suppressor and inactivate cancer-promoting inflammation. However, role of miR-218 on hepatocellular carcinoma (HCC) remains unclear. To determine the contribution of miR-218 genetic predisposition and its interaction with hepatitis B virus (HBV) mutations to HCC risk. METHODS rs11134527 located at putative promoter region of pre-miR-218 was genotyped in 1012 healthy controls, 302 hepatitis B surface antigen (HBsAg… CONTINUE READING

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