Association of a polymorphism of the matrix metalloproteinase-9 gene with bone mineral density in Japanese men.

@article{Yamada2004AssociationOA,
  title={Association of a polymorphism of the matrix metalloproteinase-9 gene with bone mineral density in Japanese men.},
  author={Yoshiji Yamada and Fujiko Ando and Naoakira Niino and Hiroshi Shimokata},
  journal={Metabolism: clinical and experimental},
  year={2004},
  volume={53 2},
  pages={
          135-7
        }
}
Matrix metalloproteinase-9 (MMP-9) is implicated in bone remodeling. A - 1562C--> T polymorphism in the promoter of the MMP-9 gene (MMP9) has been shown to influence gene transcription. The possible relation of this polymorphism to bone mineral density (BMD) was examined in 1,114 Japanese men and 1,087 women. BMD for the total body, lumbar spine, femoral neck, trochanter, or Ward's triangle was significantly lower in the combined group of men with the CT or TT genotypes or in men with the CT… CONTINUE READING