Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants.

@article{Perlis2008AssociationOA,
  title={Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants.},
  author={Roy H. Perlis and Daphne J. Holt and Jordan W. Smoller and Anne J. Blood and Sang Wook Lee and Byoung Woo Kim and Myung Joo Lee and Mei Sun and Nikos Makris and David K Kennedy and Kathryn O Rooney and Darin D. Dougherty and Rick Hoge and Jerrold F. Rosenbaum and Maurizio Fava and James Gusella and Gregory P. Gasic and Hans C. Breiter},
  journal={Archives of general psychiatry},
  year={2008},
  volume={65 8},
  pages={882-92}
}
CONTEXT Previous functional neuroimaging studies have identified a network of brain regions that process aversive stimuli, including anger. A polymorphism near the cyclic adenosine monophosphate response element binding protein gene (CREB1) has recently been associated with greater self-reported effort at anger control as well as risk for antidepressant treatment-emergent suicidality in men with major depressive disorder, but its functional effects have not been studied. OBJECTIVE To… CONTINUE READING
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