Association of a polymorphism in the betacellulin gene with type 1 diabetes mellitus in two populations

@article{Silver2006AssociationOA,
  title={Association of a polymorphism in the betacellulin gene with type 1 diabetes mellitus in two populations},
  author={Kristi D Silver and Victoria L. Magnuson and Magdalena I. Tolea and Jian Wang and William A. Hagopian and Braxton D. Mitchell},
  journal={Journal of Molecular Medicine},
  year={2006},
  volume={84},
  pages={616-623}
}
Betacellulin, a member of the epidermal growth factor family, is expressed in fetal and adult pancreas. In vitro and in vivo studies suggest a role for betacellulin in islet neogenesis and regeneration. Therefore, a mutation in the betacellulin gene might lead to fewer beta cells. With reduced beta cell reserve, beta cells may not be able to compensate for an autoimmune attack, and in turn, susceptibility to type 1 diabetes mellitus (T1DM) would increase. Previous mutational analysis identified… 
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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