Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population.

@article{Li2002AssociationOA,
  title={Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population.},
  author={Cheuk M Li and Sarah J. Campbell and Dinakantha Kumararatne and Richard John Bellamy and Cyril Ruwende and K W Mcadam and Adrian V S Hill and D. Anthony Lammas},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={186 10},
  pages={1458-62}
}
Adenosine triphosphate (ATP) ligation of P2X(7) receptors expressed on human macrophages that are infected with mycobacteria induces cell death and subsequent loss of intracellular bacterial viability. Marked heterogeneity observed in cell donor ATP responsiveness suggests that this antimycobacterial mechanism may be genetically regulated. Five single-nucleotide polymorphisms (SNPs) previously identified in a putative 1.8-kb promoter region upstream of P2RX7 exon 1 were screened for… CONTINUE READING