Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events.

@article{Shah2010AssociationOA,
  title={Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events.},
  author={Svati H. Shah and James R. Bain and Michael J. Muehlbauer and Robert A. Moffitt Johns Hopkins University David Stevens and David R. Crosslin and Carol Haynes and Jennifer R Dungan and Laura Kristin Newby and Elizabeth R. Hauser and Geoffrey S. Ginsburg and Christopher B. Newgard and William E Kraus},
  journal={Circulation. Cardiovascular genetics},
  year={2010},
  volume={3 2},
  pages={207-14}
}
BACKGROUND Molecular tools may provide insight into cardiovascular risk. We assessed whether metabolites discriminate coronary artery disease (CAD) and predict risk of cardiovascular events. METHODS AND RESULTS We performed mass-spectrometry-based profiling of 69 metabolites in subjects from the CATHGEN biorepository. To evaluate discriminative capabilities of metabolites for CAD, 2 groups were profiled: 174 CAD cases and 174 sex/race-matched controls ("initial"), and 140 CAD cases and 140… CONTINUE READING

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