Association of a group I intron with its splice junction in 50S ribosomes: implications for intron toxicity.

@article{Nikolcheva1997AssociationOA,
  title={Association of a group I intron with its splice junction in 50S ribosomes: implications for intron toxicity.},
  author={T Nikolcheva and Sarah A Woodson},
  journal={RNA},
  year={1997},
  volume={3 9},
  pages={1016-27}
}
The effect of genetic context on splicing of group I introns is not well understood at present. The influence of ribosomal RNA conformation on splicing of rDNA introns in vivo was investigated using a heterologous system in which the Tetrahymena group I intron is inserted into the homologous position of the Escherichia coli 23S rRNA. Mutations that block splicing in E. coli result in accumulation of unspliced 23S rRNA that is assembled into 50S complexes, but not 70S ribosomes. The data… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…