Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.

@article{Orozco2005AssociationOA,
  title={Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.},
  author={Gisela Orozco and Elena S{\'a}nchez and Miguel A Gonz{\'a}lez-Gay and Miguel {\'A}ngel L{\'o}pez-Nevot and Bel{\'e}n Torres and Rafael C{\'a}liz and Norb{\'e}rto Ortego-Centeno and J. F. Jim{\'e}nez-Alonso and Dora Pascual-Salcedo and Alejandro Balsa and Rosario de Pablo and Antonio N{\'u}{\~n}ez-Rold{\'a}n and Mar{\'i}a-Francisca Gonz{\'a}lez-Escribano and Javier Mart{\'i}n},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 1},
  pages={219-24}
}
OBJECTIVE To assess the possible association between the PTPN22 gene 1858C-->T polymorphism and the predisposition and clinical expression of 2 systemic autoimmune diseases, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). METHODS Our study population consisted of 826 RA patients, 338 SLE patients, and 1,036 healthy subjects. All subjects were of Spanish Caucasian origin. Genotyping of the PTPN22 gene 1858C-->T polymorphism was performed by real-time polymerase chain reaction… CONTINUE READING
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