Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis.

@article{Otsuka2004AssociationOA,
  title={Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis.},
  author={Junji Otsuka and Takahiko Horiuchi and Shigeru Yoshizawa and Hiroshi Tsukamoto and Takuya Sawabe and Yuji Kikuchi and Daisuke Himeji and Takako Koyama and Hiroki Mitoma and Takeshi Watanabe and M. D. N. Harada},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 3},
  pages={871-81}
}
OBJECTIVE To investigate whether polymorphism(s) or mutation(s) in the hematopoietic cell-specific Lyn substrate 1 (HS1) gene are involved in the pathogenesis of systemic lupus erythematosus (SLE). METHODS The entire coding region of the HS1 gene was analyzed by reverse transcriptase-polymerase chain reaction/single-strand conformational polymorphism analysis. HS1-transfected WEHI-231 cells or B lymphocytes from patients with SLE were studied for apoptosis, activation, and proliferation by… CONTINUE READING