Association of a KCNA5 gene polymorphism with systemic sclerosis-associated pulmonary arterial hypertension in the European Caucasian population.

@article{Wipff2010AssociationOA,
  title={Association of a KCNA5 gene polymorphism with systemic sclerosis-associated pulmonary arterial hypertension in the European Caucasian population.},
  author={Julien Wipff and Philippe Dieud{\'e} and Micka{\"e}l Guedj and B{\'a}rbara Ruiz and Gabriela Riemekasten and Jean Luc Cracowski and Marco Matucci-Cerinic and Inga Melchers and Marc Humbert and {\'E}ric Hachulla and Paolo Air{\'o} and Elisabeth Diot and Nicolas Hunzelmann and Paolo Caramaschi and Jean Sibilia and Gabriele Valentini and Kiet Phuong Tiev and Barbara Girerd and Luc Mouthon and Valeria Riccieri and Patrick Henri Carpentier and Juergen Distler and Zahir Amoura and Ingo Helmut Tarner and Bruno Degano and J{\'e}r{\^o}me Avouac and Olivier Meyer and Andr{\'e} Kahan and Catherine Boileau and Yannick Allanore},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 10},
  pages={3093-100}
}
OBJECTIVE Pulmonary arterial hypertension (PAH) has emerged as a leading cause of death in systemic sclerosis (SSc). The genetic basis of PAH has been unraveled in recent years, with a major role played by transforming growth factor β receptors; however, some other candidate genes have also been advocated, including potassium voltage-gated channel, shaker-related subfamily, member 5 (KCNA5). We undertook this study to determine whether KCNA5 polymorphisms confer susceptibility to SSc and its… CONTINUE READING

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