Association of a CYP17 gene polymorphism with development of breast cancer in India.

@article{Surekha2010AssociationOA,
  title={Association of a CYP17 gene polymorphism with development of breast cancer in India.},
  author={Daminani Surekha and Kagita Sailaja and Dunna Nageswara Rao and Tirunalai Padma and Digumarthi Raghunadharao and Satti Vishnupriya},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2010},
  volume={11 6},
  pages={1653-7}
}
The human CYP17 gene, located on chromosome 10q24.3, plays a key role in sex steroid synthesis, mainly related to estrogen. A 5' UTR polymorphism involving a single base pair change in the promoter region results in increased transcriptional activity. In the present study of 250 breast cancer cases and 250 ma tched controls, the A1 genotype frequency was elevated in the disease group, while the A2 genotype frequency demonstrated no association. When data were stratified by risk conferring group… CONTINUE READING