Association of XRCC1 variants with acute skin reaction after radiotherapy in breast cancer patients.

@article{Zhou2010AssociationOX,
  title={Association of XRCC1 variants with acute skin reaction after radiotherapy in breast cancer patients.},
  author={Liqing Zhou and Jianhong Xia and Hongliang Li and Jianrong Dai and Yimin Hu},
  journal={Cancer biotherapy & radiopharmaceuticals},
  year={2010},
  volume={25 6},
  pages={681-5}
}
After irradiation results in cytotoxic effects by DNA damage, base excision repair (BER) pathway is involved in the repair of single-strand breaks and nonhomologous end joining and homologous repair of double-strand breaks caused by radiotherapy. Alterations in the function of BER DNA repair genes may affect DNA repair proficiency and influence the response of patients with cancer to radiotherapy. The association of single nucleotide polymorphisms of BER DNA repair X-ray repair cross… CONTINUE READING
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