Association of V227A PPARalpha polymorphism with altered serum biochemistry and alcohol drinking in Japanese men.

@article{Naito2006AssociationOV,
  title={Association of V227A PPARalpha polymorphism with altered serum biochemistry and alcohol drinking in Japanese men.},
  author={Hisao Naito and Osamu Yamanoshita and Michihiro Kamijima and Takahiko Katoh and Tadashi Matsunaga and Chul-Ho Lee and Heon Kyu Kim and Toshifumi Aoyama and Frank J. Gonzalez and Tamie Nakajima},
  journal={Pharmacogenetics and genomics},
  year={2006},
  volume={16 8},
  pages={569-77}
}
OBJECTIVES Peroxisome proliferator-activated receptor (PPAR) alpha plays a major role in alcoholic liver disease in rodents. The two-fold objective of our study was to determine the presence of PPARalpha polymorphisms and their frequencies in Japanese populations and then to evaluate the effects of any alleles on metabolic parameters and alcohol drinking. METHODS Analysis of coding SNP in PPARalpha was performed in 706 Japanese men; from these subjects 655 men were further studied after… CONTINUE READING