Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer

@article{Fujita2009AssociationOU,
  title={Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer},
  author={Ken-Ichi Fujita and Yuichi Ando and Wataru Yamamoto and Toshimichi Miya and Hisashi Endo and Yu Sunakawa and Kazuhiro Araki and Keiji Kodama and Fumio Nagashima and Wataru Ichikawa and Masaru Narabayashi and Yuko Akiyama and Kaori Kawara and Mari Shiomi and Hiroyasu Ogata and Hiroyasu Iwasa and Yasushi Okazaki and Takashi Hirose and Yasutsuna Sasaki},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2009},
  volume={65},
  pages={251-258}
}
PurposeTo investigate the effects of genetic polymorphisms on morphine-induced adverse events in cancer patients.MethodsWe examined the relation of morphine-related adverse events to polymorphisms in UDP-glucuronosyltransferase (UGT) 2B7, ATP-binding cassette, sub-family B, number 1 (ABCB1), and μ-opioid receptor 1 genes in 32 Japanese cancer patients receiving oral controlled-release morphine sulfate tablets.ResultsThe T/T genotype at 1236 or TT/TT diplotype at 2677 and 3435 in ABCB1 was… 

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