Association of Tumor Necrosis Factor-α-863C/A Gene Polymorphism with Chronic Obstructive Pulmonary Disease

@article{Chen2010AssociationOT,
  title={Association of Tumor Necrosis Factor-α-863C/A Gene Polymorphism with Chronic Obstructive Pulmonary Disease},
  author={Yung-Che Chen and S F Liu and Chien-Hung Chin and Chao-Chien Wu and Chung-Jen Chen and Hsueh-wen Chang and Yi-Hsi Wang and Y H Chung and Tung-Ying Chao and Meng-Chih Lin},
  journal={Lung},
  year={2010},
  volume={188},
  pages={339-347}
}
The aim of this study was to investigate genetic effects on the pathogenesis of chronic obstructive pulmonary disease (COPD). The study was conducted as a prospective case–control study in a medical center in southern Taiwan. The patient group consisted of 145 male patients with smoking-related COPD and a control group of 139 resistant smokers from July 2004 to September 2009. We compared allele and genotype frequencies of three tag single nucleotide polymorphisms (SNP) of the TNF-α gene… CONTINUE READING

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Tumor necrosis factor-α -863 C/A promoter polymorphism affects the inflammatory response after cardiac surgery.

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