Association of Transforming Growth Factor-b1 (TGFb1) T29?C Gene Polymorphism with Bone Mineral Density (BMD), Changes in BMD, and Serum Concentrations of TGF-b1 in a Population-Based Sample of Postmenopausal German Women

@article{Hinke2001AssociationOT,
  title={Association of Transforming Growth Factor-b1 (TGFb1) T29?C Gene Polymorphism with Bone Mineral Density (BMD), Changes in BMD, and Serum Concentrations of TGF-b1 in a Population-Based Sample of Postmenopausal German Women},
  author={Vera Hinke and Thomas Seck and Christof Clanget and Christa Scheidt-Nave and Reinhard Ziegler and Johannes Pfeilschifter},
  journal={Calcified Tissue International},
  year={2001},
  volume={69},
  pages={315-320}
}
TGF-beta1 is thought to play an important role in bone turnover. Thus, the gene encoding TGF-beta1 is a prime candidate for the genetic regulation of bone density. Recent studies have suggested that a T29 --> C polymorphism in the signal sequence region of the TGF-beta1 gene may be related to bone mineral density (BMD) and bone loss in postmenopausal Japanese women. In the present study, we examined the relationship between this polymorphism and BMD in a population-based sample of 102 estrogen… CONTINUE READING

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