Association of Toll-like receptor 3 and Toll-like receptor 9 single-nucleotide polymorphisms with hepatitis C virus persistence among Egyptians

@article{Hamdy2018AssociationOT,
  title={Association of Toll-like receptor 3 and Toll-like receptor 9 single-nucleotide polymorphisms with hepatitis C virus persistence among Egyptians},
  author={Shaimaa Mohamed Hamdy and Ahmed Sheikh Mohamed Osman and Zainab A. Zakaria and Iman F. Galal and M Yakout Sobhy and Mohamed Hossni Hashem and Walaa Ramadan Allam and Mohamed Abdel-Samiee and Eman Rewisha and Imam Waked and Sayed F Abdelwahab},
  journal={Archives of Virology},
  year={2018},
  volume={163},
  pages={2433-2442}
}
Toll-like receptors (TLRs) give the innate immune system a considerable specificity for a large range of pathogens. TLR3 detects dsRNA of viruses while TLR9 recognizes bacterial and viral unmethylated CpG motifs. This study examined whether there is a potential association between single-nucleotide polymorphisms (SNPs) in the TLR3.rs3775290 (c.1377C/T), TLR9.rs5743836 (-1237T→C) and TLR9.rs352140 (G2848A) genes and HCV infection among Egyptian patients and healthcare workers (HCWs). We enrolled… CONTINUE READING
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