Association of Toll-Like Receptor 3 and Toll-Like Receptor 9 Single Nucleotide Polymorphisms with Hepatitis C Virus Infection and Hepatic Fibrosis in Egyptian Patients.

@article{Zayed2017AssociationOT,
  title={Association of Toll-Like Receptor 3 and Toll-Like Receptor 9 Single Nucleotide Polymorphisms with Hepatitis C Virus Infection and Hepatic Fibrosis in Egyptian Patients.},
  author={Rania A Zayed and Dalia Abdelhamid Omran and Doha Abdel-Hamid Mokhtar and Zinab Zakaria and Sameera Ezzat and Mohamed A. Soliman and Lamiaa Mobarak and Hossam El-Sweesy and Ghada Emam},
  journal={The American journal of tropical medicine and hygiene},
  year={2017},
  volume={96 3},
  pages={
          720-726
        }
}
Toll-like receptors (TLRs) are recognized as fundamental contributors to the immune system function against infections. Hepatitis C virus (HCV) infection represents a global health problem especially in Egypt having the highest HCV prevalence worldwide where HCV infection is a continuing epidemic. The aim of the present study was to investigate the possible association between genetic variation in TLR-3 and TLR-9 and HCV infection and hepatic fibrosis in chronic HCV-positive Egyptian patients… CONTINUE READING