Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection

@inproceedings{AlAnazi2017AssociationOT,
  title={Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection},
  author={Mashael R. Al-Anazi and Sabine Matou-Nasri and Ayman A. Abdo and Faisal M Sanai and Saad H Alkahtani and Saud Alarifi and Abdullah A. Alkahtane and Hamad Al-Yahya and Daoud Ali and Mohammed S. Alessia and Bushra Alshahrani and Mohammed N. Al-Ahdal and Ahmed A Al-Qahtani},
  booktitle={Journal of immunology research},
  year={2017}
}
Toll-like receptor 3 (TLR3) plays a key role in innate immunity by recognizing pathogenic, double-stranded RNAs. Thus, activation of TLR3 is a major factor in antiviral defense and tumor eradication. Although downregulation of TLR3 gene expression has been mainly reported in patients infected with hepatitis C virus (HCV), the influence of TLR3 genotype on the risk of HCV infection, HCV-related cirrhosis, and/or hepatocellular carcinoma (HCC) remains to be determined. Single-nucleotide… CONTINUE READING

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