Association of TNFA -308 G/A and TNFRI +36 A/G gene polymorphisms with glaucoma.

  title={Association of TNFA -308 G/A and TNFRI +36 A/G gene polymorphisms with glaucoma.},
  author={M Reza Razeghinejad and Feisal Rahat and Eskandar Kamali-Sarvestani},
  journal={Ophthalmic research},
  volume={42 3},
OBJECTIVE TNF-alpha is one of the most important factors recognized in the pathogenesis of open-angle glaucoma. Therefore, the association of single nucleotide polymorphisms in the TNFRI gene and the promoter region of the TNFA gene with glaucoma susceptibility was investigated in the present study. METHOD In total, 223 patients with glaucoma and 202 unrelated controls were genotyped by allele-specific oligonucleotide PCR and PCR- restriction fragment length polymorphism to determine TNFA… CONTINUE READING
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